Vulnerability to osteoarthritis from antagonistic pleiotropy at loci that induce short stature to protect against freezing?

Capellini, T. D., Chen, H., Cao, J., Doxey, A. C., Kiapour, A. M., Schoor, M., & Kingsley, D. M. (2017). Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nature Genetics. (only a preview, article is behind a paywall, but a preprint is available here.) A noncoding single base pair polymorphism […]

from The Evolution and Medicine Review http://ift.tt/2sEUvtS